George Cooper is joined by Perry Elliott, Professor of Cardiovascular Medicine at University College London, UK, and Anjali Owens, Associate Professor of Medicine in the Division of Cardiology at the Perelman School of Medicine of the University of Pennsylvania, USA. Following an incredible symposium session at the 2024 European Society of Cardiology (ESC) Congress, they discuss case studies and real-world evidence relating to hypertrophic cardiomyopathy and the use of mavacamten.