S1 EP5: The use of SGLT2 inhibitors in patients hospitalised for acute heart failure

Episode 5 - The use of SGLT2 inhibitors in patients hospitalised for acute heart failure - Prof. Christiane Angermann

We are joined by Professor Christiane Angermann. Prof Angermann is a Senior Professor of Medicine and Clinical Research in Cardiology at the University and University Hospital Würzburg in Germany, and co-founder of the Comprehensive Heart Failure Centre Würzburg (CHFC). She acted as coordinating investigator in the Executive Committee of the EMPULSE trial, a multinational clinical trial evaluating the clinical benefit of empagliflozin in patients who were stabilised after hospitalisation for acute heart failure. She has published over 240 peer-reviewed articles and is currently editor-in-chief for Current Heart Failure Reports.

For this episode, we will explore the potential for the use of empagliflozin in patients who are hospitalised with heart failure.

References:

Voors, AA, et al. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial. Nat. Med., 2022; 28,: 568–574. https://doi.org/10.1038/s41591-021-01659-1

Biegus, J, et al. Impact of empagliflozin on decongestion in acute heart failure: the EMPULSE trial, European Heart Journal, 2022; ehac530, https://doi.org/10.1093/eurheartj/ehac530

Mebazaa, A, et al. Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial.

Lancet. 2022; 400: 1938–1952. https://doi.org/10.1016/S0140-6736(22)02076-1

Voors, AA, et al. Effects of Empagliflozin on Symptoms, Physical Limitations, and Quality of Life in Patients Hospitalized for Acute Heart Failure: Results From the EMPULSE Trial. Circulation 2022; 146: 279–288. https://doi.org/10.1161/CIRCULATIONAHA.122.059725

Emmens, JE, et al. Worsening renal function in acute heart failure in the context of diuretic response. Eur J Heart Fail. 2022;  24: 365-374. https://doi.org/10.1002/ejhf.2384

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